Ledipasvir/Sofosbuvir — Blue Cross Blue Shield of Kansas
Hepatitis C genotype 4
Preferred products
- Epclusa (sofosbuvir/velpatasvir)
- Harvoni (ledipasvir/sofosbuvir)
- Mavyret (glecaprevir/pibrentasvir)
- Zepatier (elbasvir/grazoprevir)
Initial criteria
- The patient has a diagnosis of hepatitis C genotype 1, 4, 5, or 6 AND
- The prescriber has provided the patient’s baseline HCV RNA level if genotype 1 AND
- ONE of the following: treatment naive OR previously treated with peg-interferon and ribavirin with or without an HCV protease inhibitor OR has decompensated cirrhosis AND
- The prescriber has screened for current or prior HBV infection AND if positive, will monitor for HBV flare or reactivation AND
- If the patient has an FDA labeled indication, then age is within labeling for the requested indication OR there is support for use in the patient’s age for that indication AND
- If the client has preferred agent(s), then ONE of the following: requested agent is preferred OR patient has been treated with non-preferred agent in past 30 days OR patient has intolerance, hypersensitivity, or contraindication to ALL preferred agents OR there is support for use of non-preferred agent over preferred agents AND
- ONE of the following: prescriber is specialist (gastroenterologist, hepatologist, infectious disease) or has consulted one OR all of the following: treatment naive, no or compensated cirrhosis, requested agent supported in AASLD guidelines for simplified treatment, meets all simplified treatment qualifications AND
- The patient does NOT have FDA labeled contraindications to requested agent AND
- The patient meets requirements and will use agent in regimen in Table 1 or Table 2 AND therapy length does not exceed lengths in Table 1 or Table 2
Approval duration
up to duration of treatment per Tables 1 or 2