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Ledipasvir/SofosbuvirBlue Cross Blue Shield of Kansas

Hepatitis C genotype 4

Preferred products

  • Epclusa (sofosbuvir/velpatasvir)
  • Harvoni (ledipasvir/sofosbuvir)
  • Mavyret (glecaprevir/pibrentasvir)
  • Zepatier (elbasvir/grazoprevir)

Initial criteria

  • The patient has a diagnosis of hepatitis C genotype 1, 4, 5, or 6 AND
  • The prescriber has provided the patient’s baseline HCV RNA level if genotype 1 AND
  • ONE of the following: treatment naive OR previously treated with peg-interferon and ribavirin with or without an HCV protease inhibitor OR has decompensated cirrhosis AND
  • The prescriber has screened for current or prior HBV infection AND if positive, will monitor for HBV flare or reactivation AND
  • If the patient has an FDA labeled indication, then age is within labeling for the requested indication OR there is support for use in the patient’s age for that indication AND
  • If the client has preferred agent(s), then ONE of the following: requested agent is preferred OR patient has been treated with non-preferred agent in past 30 days OR patient has intolerance, hypersensitivity, or contraindication to ALL preferred agents OR there is support for use of non-preferred agent over preferred agents AND
  • ONE of the following: prescriber is specialist (gastroenterologist, hepatologist, infectious disease) or has consulted one OR all of the following: treatment naive, no or compensated cirrhosis, requested agent supported in AASLD guidelines for simplified treatment, meets all simplified treatment qualifications AND
  • The patient does NOT have FDA labeled contraindications to requested agent AND
  • The patient meets requirements and will use agent in regimen in Table 1 or Table 2 AND therapy length does not exceed lengths in Table 1 or Table 2

Approval duration

up to duration of treatment per Tables 1 or 2