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ibrutinibCareFirst (Caremark)

Central nervous system cancers (including primary CNS lymphoma and brain metastases in lymphoma)

Initial criteria

  • Imbruvica used for relapsed or refractory disease as either a single agent or in combination with high-dose methotrexate and rituximab for primary CNS lymphoma
  • OR Imbruvica used for induction therapy as a single agent for primary CNS lymphoma
  • OR Imbruvica used as a single agent for brain metastases in lymphoma

Reauthorization criteria

  • No evidence of unacceptable toxicity or disease progression while on Imbruvica

Approval duration

12 months