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ImkeldiCareFirst (Caremark)

Aggressive Systemic Mastocytosis (ASM)

Preferred products

  • Gleevec
  • imatinib mesylate

Initial criteria

  • Used as a single agent
  • Any of the following: D816V c-KIT mutation negative, D816V c-KIT mutation status unknown, well-differentiated systemic mastocytosis, or eosinophilia present with FIP1L1::PDGFRA fusion gene

Reauthorization criteria

  • No evidence of unacceptable toxicity or disease progression while on current regimen

Approval duration

12 months