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Krazati (adagrasib)CareFirst (Caremark)

recurrent, advanced, or metastatic KRAS G12C mutation positive non-small cell lung cancer (NSCLC)

Initial criteria

  • Diagnosis of recurrent, advanced, or metastatic KRAS G12C mutation positive NSCLC
  • KRAZATI will be used as a single agent
  • Either of the following criteria are met: (a) member has received at least one prior systemic therapy and has not experienced disease progression on KRAS G12C-targeted therapy OR (b) member has brain metastases

Reauthorization criteria

  • No evidence of unacceptable toxicity or disease progression while on the current regimen

Approval duration

12 months