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lazertinibCareFirst (Caremark)

First-line treatment of recurrent, advanced, or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 19 deletion or exon 21 L858R substitution mutations in combination with amivantamab

Initial criteria

  • Diagnosis of recurrent, advanced, or metastatic NSCLC
  • Presence of EGFR exon 19 deletion or exon 21 L858R substitution mutation confirmed by test results
  • Used in combination with amivantamab (Rybrevant)
  • Requested for first-line treatment

Reauthorization criteria

  • No evidence of unacceptable toxicity while on the current regimen
  • Used for an indication listed in the coverage criteria section

Approval duration

12 months