Releuko (filgrastim-ayow) — CareFirst (Caremark)
Aplastic anemia
Preferred products
- Neupogen (filgrastim)
- Nivestym (filgrastim-aafi)
- Zarxio (filgrastim-sndz)
- Granix (tbo-filgrastim)
- Nypozi (filgrastim-txid)
Initial criteria
- The requested medication will not be used in combination with other colony stimulating factors within any chemotherapy cycle
- The member will not receive chemotherapy at the same time as they receive radiation therapy
- One of the following criteria is met:
- i. Used for primary prophylaxis in members with solid tumors or non-myeloid malignancies who have received, are currently receiving, or will be receiving:
- a. Myelosuppressive anti-cancer therapy expected to result in ≥20% incidence of febrile neutropenia (FN)
- b. Myelosuppressive anti-cancer therapy expected to result in 10–19% risk of FN and who are at high risk of FN because of bone marrow compromise, co‑morbidities, or other patient-specific risk factors
- c. Myelosuppressive anti-cancer therapy expected to result in <10% risk of FN and who have at least 2 patient-related risk factors
- ii. Used for secondary prophylaxis in members with solid tumors or non-myeloid malignancies who experienced a febrile neutropenic complication or a dose-limiting neutropenic event from a prior cycle of similar chemotherapy (for which primary prophylaxis was not received)
- iii. Used for treatment of high-risk febrile neutropenia in members with any of the following prognostic factors predictive of clinical deterioration: age >65 years OR being hospitalized at the time of fever development
Approval duration
6 months