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Apokyn (apomorphine hydrochloride) injectionHighmark

acute, intermittent treatment of 'off' episodes associated with advanced Parkinson’s disease

Preferred products

  • pramipexole
  • ropinirole
  • entacapone
  • rasagiline
  • selegiline

Initial criteria

  • Diagnosis of Parkinson’s disease (ICD-10: G20)
  • Parkinson’s disease is classified as advanced
  • Using Apokyn for the acute, intermittent treatment of 'off' episodes
  • Experiencing 'off' episodes despite an optimally dosed oral carbidopa/levodopa regimen
  • Experienced therapeutic failure, intolerance, or contraindication to both of the following: pramipexole AND ropinirole
  • Experienced therapeutic failure, intolerance, or contraindication to one of the following: entacapone OR rasagiline OR selegiline
  • If the request is for brand Apokyn, experienced therapeutic failure or intolerance to generic apomorphine hydrochloride injection

Reauthorization criteria

  • Prescriber attests that the member has experienced positive clinical response to therapy
  • If the request is for brand Apokyn, experienced therapeutic failure or intolerance to generic apomorphine hydrochloride injection

Approval duration

12 months