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metyrosineHighmark

pheochromocytoma

Preferred products

  • doxazosin
  • prazosin
  • terazosin
  • generic metyrosine

Initial criteria

  • Diagnosis of pheochromocytoma (ICD-10: C74.10) defined by one of the following: elevated metanephrines in plasma or urine OR tumor evidence from CT scan or MRI
  • Member meets one of the following: planned resection surgery OR resection surgery is contraindicated OR malignant pheochromocytoma
  • Member has experienced therapeutic failure, contraindication, or intolerance to one of the following: doxazosin OR prazosin OR terazosin
  • If request is for brand Demser, member has experienced therapeutic failure or intolerance to generic metyrosine

Reauthorization criteria

  • Member meets one of the following: incomplete response to tumor resection OR resection surgery is contraindicated OR malignant pheochromocytoma
  • Member has experienced a positive clinical response to therapy (e.g., symptom improvement, reduction in hypertensive episodes)

Approval duration

12 months