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Orserdu (elacestrant)Highmark

advanced or metastatic ER-positive, HER2-negative, ESR1-mutated breast cancer

Initial criteria

  • age ≥ 18 years
  • member is a male or a postmenopausal female
  • diagnosis of advanced or metastatic breast cancer (ICD-10: C50)
  • disease is ER-positive, HER2-negative
  • disease harbors an ESR1 mutation as detected by an FDA-approved test
  • disease progression following at least one line of endocrine therapy

Reauthorization criteria

  • prescriber attests that the member is tolerating therapy AND has experienced a therapeutic response defined as disease improvement OR delayed disease progression

Approval duration

12 months