Tryngolza (olezarsen) — Medica

Familial chylomicronemia syndrome

Initial criteria

age ≥ 18 years
fasting triglyceride level ≥ 880 mg/dL [documentation required]
Patient has undergone genetic testing and meets ONE of the following:
i. Molecular genetic test results demonstrate biallelic pathogenic variants in at least one gene causing familial chylomicronemia syndrome [documentation required] (genes may include LPL, GPIHBP1, APOA5, APOC2, or LMF1); OR
ii. Molecular genetic test results are inconclusive and the patient has ONE of the following [documentation required]:
a) familial chylomicronemia syndrome score ≥ 10; OR
b) North American familial chylomicronemia syndrome score ≥ 45; OR
c) history of pancreatitis; OR
d) history of eruptive xanthomas; OR
e) history of lipemia retinalis
Medication will be used concomitantly with a low-fat diet
Medication is prescribed by a cardiologist, endocrinologist, or physician specializing in severe hypertriglyceridemia

1 year