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NexletolMedical Mutual

Established Cardiovascular Disease

Initial criteria

  • Patient age ≥ 18 years
  • Patient has had one of the following: previous myocardial infarction or a history of an acute coronary syndrome OR angina (stable or unstable) OR past history of stroke or transient ischemic attack OR coronary artery disease OR peripheral arterial disease OR undergone coronary or other arterial revascularization (e.g., CABG, PCI, angioplasty, stent)
  • Patient meets ONE of the following: (a) Patient has tried one high-intensity statin (atorvastatin ≥ 40 mg or rosuvastatin ≥ 20 mg daily [single or combo]) AND tried one high-intensity statin + ezetimibe for ≥ 8 weeks AND LDL-C after regimen remains ≥ 55 mg/dL OR (b) Statin intolerant defined as statin-related rhabdomyolysis OR skeletal muscle symptoms that occurred on trials of both atorvastatin and rosuvastatin and resolved upon discontinuation

Reauthorization criteria

  • According to prescriber, patient has experienced a response to therapy (e.g., decreasing LDL-C, total cholesterol, non-HDL-C, or apolipoprotein B)

Approval duration

1 year