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Tezspire (tezepelumab-ekko) Pre-filled PenPoint32Health

severe asthma

Initial criteria

  • Diagnosis of severe asthma OR current treatment with an alternative biologic indicated for moderate to severe asthma
  • Patient age ≥ 12 years
  • Prescribed by or in consultation with an allergist, immunologist, or pulmonologist
  • History within the past 12 months of two or more asthma exacerbations requiring oral or injectable corticosteroid treatment OR one asthma exacerbation resulting in hospitalization
  • Patient currently maintained on a maximally tolerated inhaled corticosteroid plus at least one other asthma maintenance medication (e.g., long-acting inhaled beta2-agonist, long-acting muscarinic antagonist, leukotriene receptor antagonist)
  • Patient will not be concurrently treated with an alternative biologic for asthma

Reauthorization criteria

  • Documented diagnosis of severe asthma
  • Patient age ≥ 12 years
  • Prescribed by or in consultation with an allergist, immunologist, or pulmonologist
  • Patient experienced a therapeutic response as defined by one of the following: increase in percent predicted FEV1 from pretreatment baseline, reduction in dose of inhaled corticosteroids required to control asthma, reduction in asthma exacerbations (e.g., decreased frequency of unscheduled emergency department/urgent care visits), reduction in asthma symptoms (e.g., chest tightness, coughing, shortness of breath, nocturnal awakenings), or reduction in the use of oral corticosteroids to treat and/or prevent asthma exacerbations
  • Patient will not be concurrently treated with an alternative biologic for asthma

Approval duration

initial 6 months, reauth 12 months