Dupixent (dupilumab) — United Healthcare

eosinophilic esophagitis

Initial criteria

Diagnosis of eosinophilic esophagitis
Symptoms of esophageal dysfunction (e.g., dysphagia, food impaction, chest pain, heartburn, upper abdominal pain)
Eosinophil-predominant inflammation on biopsy: ≥15 intraepithelial eosinophils per high power field (or 60 eosinophils per mm2)
Secondary causes of esophageal eosinophilia excluded
Mucosal eosinophilia isolated to esophagus and symptoms persist after an 8-week trial of at least one: (a) Proton pump inhibitor, (b) Topical (esophageal) corticosteroid
Not used with anti-IL5, anti-IgE, or TSLP inhibitors
Prescribed by a Gastroenterologist or Allergist

Positive clinical response (improvement in symptoms, histologic, or endoscopic measures)
Not used with anti-IL5, anti-IgE, or TSLP inhibitors

12 months