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Mektovi (binimetinib)United Healthcare

Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST)

Preferred products

  • imatinib mesylate (Gleevec)

Initial criteria

  • Diagnosis of succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST)
  • Disease is one of the following: gross residual disease (R2 resection), unresectable primary disease, tumor rupture, progressive, recurrent, or metastatic
  • Used in combination with imatinib mesylate (Gleevec)

Reauthorization criteria

  • Patient does not show evidence of progressive disease while on Mektovi therapy
  • Used in combination with imatinib mesylate (Gleevec)

Approval duration

12 months