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Orilissa 150 mg (elagolix)United Healthcare

moderate to severe pain associated with endometriosis

Initial criteria

  • Diagnosis of moderate to severe pain associated with endometriosis
  • Failure after a 3-month trial (e.g., inadequate pain relief), contraindication, or intolerance of two analgesics (e.g., ibuprofen, meloxicam, naproxen)
  • Failure after a 3-month trial, contraindication, or intolerance to one of the following: hormonal contraceptives OR progestins [e.g., norethindrone (generic Aygestin)]
  • Prescribed by or in consultation with an Obstetrician/Gynecologist (OB/GYN) OR reproductive endocrinologist

Reauthorization criteria

  • Documentation of positive clinical response to therapy
  • Impact to bone mineral density has been considered
  • Treatment duration has not exceeded a total of 24 months

Approval duration

12 months (initial and reauthorization) up to a maximum treatment duration of 24 months