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Piqray (alpelisib)United Healthcare

Breast cancer

Initial criteria

  • Diagnosis of breast cancer
  • Advanced OR Metastatic disease
  • Disease is hormone receptor (HR)-positive
  • Disease is human epidermal growth factor receptor 2 (HER2)-negative
  • Presence of one or more PIK3CA mutations
  • Used in combination with fulvestrant
  • Disease has progressed on or after an endocrine-based regimen

Reauthorization criteria

  • Patient does not show evidence of progressive disease while on Piqray therapy

Approval duration

12 months