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The Policy VaultThe Policy Vault

Radicava ORS (edaravone)United Healthcare

amyotrophic lateral sclerosis (ALS)

Initial criteria

  • EITHER both of the following:
  • (1) Patient has been established on therapy with edaravone for ALS under an active UnitedHealthcare medical benefit prior authorization
  • AND (2) All of the following:
  • • Diagnosis of ALS
  • • Prescribed by, or in consultation with, a neurologist with expertise in the diagnosis of ALS
  • • Patient is currently receiving edaravone therapy
  • • Patient is not dependent on invasive ventilation
  • OR all of the following:
  • (1) Submission of medical records (e.g., chart notes, previous medical history, diagnostic testing including imaging, nerve conduction studies, laboratory values) to support the diagnosis of ALS
  • AND (2) Prescribed by, or in consultation with, a neurologist with expertise in the diagnosis of ALS
  • AND (3) Submission of the most recent ALS Functional Rating Scale-Revised (ALSFRS-R) score confirming that the patient has scores ≥ 2 in all items of the ALSFRS-R criteria at the start of treatment
  • AND (4) Submission of medical records (e.g., chart notes, laboratory values) confirming that the patient has a percent forced vital capacity (%FVC) ≥ 80% at the start of treatment

Reauthorization criteria

  • Diagnosis of ALS
  • Prescribed by, or in consultation with, a neurologist with expertise in the diagnosis of ALS
  • Patient is currently receiving Radicava ORS therapy
  • Patient is not dependent on invasive ventilation

Approval duration

12 months