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Spravato (esketamine)United Healthcare

Major depressive disorder (treatment-resistant)

Initial criteria

  • Diagnosis of major depressive disorder (treatment-resistant)
  • Patient has not experienced a clinically meaningful improvement after treatment with at least two different antidepressants
  • Provider and/or the provider’s healthcare setting is certified in the Spravato REMS program

Reauthorization criteria

  • Documentation of positive clinical response to Spravato therapy
  • Provider and/or the provider’s healthcare setting is certified in the Spravato REMS program

Approval duration

12 months