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Tarceva (erlotinib)United Healthcare

Central Nervous System (CNS) Cancers

Initial criteria

  • Diagnosis of brain, leptomeningeal, or spine metastases from NSCLC
  • Tumors are positive for one of the following: EGFR exon 19 deletions OR exon 21 (L858R) substitution mutations OR a known sensitizing EGFR mutation (e.g., S768I, L861Q, G719X)

Reauthorization criteria

  • Patient does not show evidence of progressive disease while on Tarceva therapy

Approval duration

12 months