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The Policy VaultThe Policy Vault

Xalkori (crizotinib)United Healthcare

Non-Small Cell Lung Cancer (NSCLC)

Preferred products

  • Alecensa (alectinib)
  • Alunbrig (brigatinib)
  • Lorbrena (lorlatinib)

Initial criteria

  • Diagnosis of non-small cell lung cancer (NSCLC)
  • Disease is metastatic OR recurrent OR advanced
  • Tumor is ROS1-positive OR positive for mesenchymal-epithelial transition (MET) amplification OR positive for MET exon 14 skipping mutation OR (tumor is ALK-positive AND (provider attests contraindication/intolerance/inappropriateness to Alecensa (alectinib), Alunbrig (brigatinib), and Lorbrena (lorlatinib)) OR (patient currently on Xalkori AND patient has not received manufacturer sample assistance or free trial))

Reauthorization criteria

  • Patient does not show evidence of progressive disease while on Xalkori therapy

Approval duration

12 months